Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
But not every reporter (including this one) would agree with the final assessment.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Writing for a Mini-Series or Movie: D.V. DeVincentis, “The People v. O. J. Simpson: American Crime Story” (“Marcia, Marcia, Marcia”)
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The London school’s MBA is ranked first in Europe, its EMBA programme, delivered jointly with Columbia Business School in the US, is ranked third and its MiM programme is in the top 10 on its first participation. The MiM ranking was the last missing piece for LBS to come first in Europe.
Trends and targets in antiviral phototherapy
Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?
Honda has recalled more than 10 million vehicles in the U.S. to fix a potentially fatal defect in air bags made by Japanese supplier, Takata. The air bag inflators can rupture after a crash and injure occupants with shards of metal. Honda has confirmed three deaths and 48 injuries in connection with such incidents.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
May the coming New Year bring you joy, love and peace.
ACE2 as a potential therapeutic target for pandemic COVID-19
But the economic base for these capabilities is steadily declining.
值得注意的是，本年度传播假消息之首的网站域名当属“abcnews.com.co.” 在十一月的一次Verge的采访中，伊利诺伊州大学信息科学学院的Nicole A. Cooke教授引用了一个假新闻网站上的消息，这个假新闻网站使用的是危险和普遍的策略，即域名和真网站看上去只有微小的区别。他们让消息源从第一眼看上去具备真实性。管理abcnews.com.co的人告诉华盛顿邮报，他相信他的网站在特朗普大选期间充当了一个重要的因素。
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
As China clears the way forfreer markets and increased foreign participation, fortifies the infrastructureof its burgeoning cities, and creates the social conditions for middle classfamilies to grow in size, confidence, and spending power, watch for continuedgrowth in the world’s second biggest economy in 2014 and beyond.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Justin Bieber rounded out the top five, honoured for his work with Pencils of Promise and his Believe Charity Drive.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
5.Britons love bleak humour: that's why all the hire bikes are branded with the name of a bank currently being investigated for fixing interest rates. It's supposed to be funny.
In 2010, the Martin Aircraft Company introduced a jetpack it called "the world's first piratical jetpack." The jetpack even won a spot in Time's Top 50 Inventions of 2010. While its development has been on since 1981, the world's first jetpack is known to have flown in 1958. It was designed by Wendell Moore, a researcher at Bells Aerosystems. Early prototypes of Wendell's jetpack could reach a height of 5 meters (16 ft) and remain airborne for three minutes. This attracted the attention of the US Army, which funded the project with $150,000. Several test flights were later done for the US Army and even for JFK himself. The army later stopped paying for more research into the project because the flight time and distance were not convincing enough. NASA also wanted to use the jetpack for their Apollo 11 mission to serve as backups in case their lunar module malfunctioned. They later changed their minds, going for the lunar rover instead. After this setback, Bell discontinued further research on the jetpack.
All but one of the other top 10 categories reflected public fascination with celebrities. Teen pop sensation Miley Cyrus was in third place in the search rankings and television personality Kim Kardashianwas not far behind at fourth place. They were followed by Lady Gaga at No. 5, actress Megan Fox in seventh place, with Justin Bieber, American Idol and Britney Spears completing the top 10. The iPhone stood out as the exception, coming in sixth.
Surveys indicate that a majority of women suffer or have suffered gender prejudice when looking for a job, because employers do not want to grant maternity leave. To avoid possible gender discrimination from employers as a result of their entitlement to maternity leave and increase their employment competitiveness, some female job seekers have reportedly chosen to get married and have their children before graduating from universities.
Influenza neuraminidase: A druggable target for natural products
Employers have stepped up their hiring recently, adding 171,000 jobs in October and an average of 157,000 a month so far this year. That's a better pace than last year and the strongest job growth since 2006, Labor Department data show.[qh]
在《醉乡民谣》(Inside Llewyn Davis)中，编剧兼导演乔尔?科恩(Joel Coen)和伊桑?科恩(Ethan Coen)兄弟俩挥之不去的忧伤情绪转化成了令人难忘的戏剧性场面。我觉得我的评论本应澄清，这部关于流行文化牺牲品的悲歌有一种特别的味道；其中一些部分相当阴郁。奥斯卡?伊萨克(Oscar Isaac)在片中出演一位自暴自弃的民谣乐手，宿命般地献身于他的艺术，他的卓越表演令这部影片极其震撼人心。
“These students have absolutely no free speech rights that were violated in this context."
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Pete Rossi can count on one hand the number of weeks out of the year that he works more than 50 hours. But the rest of the year, his job as an actuary with the Department of Defense, provides a good living with a minimum of stress.
Colliding Neutron Stars
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The runner-up was Lucy Kay, with Bars and Melody in third place.
In the 2013 survey, Tokyo reclaimed the title as the world's most expensive city. Currency swings pushed Zurich into the No.1 position last year but government exchange rate controls have driven the Swiss city back to No.7 in the list. Osaka in Japan was ranked the second most expensive.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
However, this year it is ranked in eighth place.
Morocco is a gateway to Africa. Major tourism cities in the North African kingdom include the capital of Rabat, Casablanca – the country's largest city - Marrakesh and Agadir.
Cullinan and Ruiz each carry a suitcase containing a copy of the winning envelope for all the categories - meaning there are two envelopes for each award.
Mr Erdogan’s escalation comes in the midst of a vitriolic tit-for-tat between Ankara and The Hague, which began at the weekend after Dutch officials barred Turkish ministers from campaigning in Turkish communities inside the Netherlands.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
9. “The Big Short” Adam McKay plays it for comedy, but as he carpet-bombs the screen with laughs, he makes it clear that his take on the 2008 economic meltdown is a staggering American tragedy.
4.A Sex Video
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
While Switzerland’s University of St Gallen retains the top spot, French and British business schools, with 24 and 18 programmes respectively, are the backbone of the 2017 FT ranking of 95 programmes around the world. More than half of UK schools move up the ranking, compared with one in France. A third of British schools rise five places, in contrast to the two-thirds of French schools that drop five or more places.
The studio says it has taken the step because the boy declined to remove a YouTube video he published which promoted how to use the software.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
《在巴基斯坦的争斗中，玛丽亚姆·谢里夫正处在权力的边缘，也或许是监狱》(In Pakistani Fray, Maryam Sharif Is on the Edge of Power, or Prison)
In the three years after the death of Steve Jobs, Mr Cook, 54, has held his nerve through attacks from activist investors and a loss of faith among some that Apple could succeed without its late founder. This year has seen Apple’s chief step out of the shadows of his predecessor and imprint the company with his own set of values and priorities: bringing in fresh blood, changing how it manages its cash pile, opening Apple up to greater collaboration and focusing more on social issues.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The renewal of the 70-year term of land-use rights by urban-dwelling owners will be no problem. No application needs to be filed, there will be no preset conditions and it will not affect any deal being made over the property.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Peer review is an evaluation of work by one or more people of similar competence to those who produce the work, which helps validate research.
圣保罗报的民意调查是基于在贝洛奥里藏特（Belo Horizonte）的米内朗球场（ Mineirao）对693名球迷进行的采访，统计误差为4%左右。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
A disturbing and often bleak analysis of the automated future of work has been named 2015’s business book of the year.
Her real-life sister Lexie often accompanies her dressed as Elsa's sister Princess Anna from the movie, and her best friend steps in when Lexie isn't available.
In October, the government announced that it was ending the decades-old "one-child policy," which restricted the number of children that married couples are allowed to have. The new regulations will not take effect until next year.
The eighth grader's candidacy is also about overcoming age discrimination, which he sees as a barrier to equality, and he says his quest for the top state spot is no joke.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Stephen Curry scored 37 points to lead the defending NBA champions to their 12th straight win to open the season, a hard-fought 115-110 victory over the Toronto Raptors on Tuesday night.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Only 6.92 percent of Hawaiian’s flights arrived late during the past three years, almost twice as good as the runner up, Alaska Air — 11.27 percent of its flights arrived late.
China is the most striking wild card that will drive agricultural markets, said Stefan Vogel, head of agri commodity markets at Rabobank,
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Though the 60-year-old Microsoft head is 4.2 billion dollars poorer than 2015, his net worth of 75 billion dollars has put him in the top spot of the spot on Forbes' World Billionaires list for the third year in a row, after overcoming Mexico's Carlos Slim Helu in 2014.
It’s ironic that in a country as populous as China, a meme about loneliness would be so popular. This seemingly irrational line has been repeated in every possible permutation, on every possible occasion, e.g. “What big brother is reading not a book, but loneliness.”
The Sixers are still slowly pivoting from a full-on institutional tank job to trying to be competitive, and the Suns are not expecting to be anything like good. So those two teams are quasi-tanking. They are, at least, not mad about losing.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Ultimately I expect these new leaders to start selecting from a broader pool of candidates and appoint direct reports from more varied backgrounds, defying those who use current imbalances to extrapolate gloomily that leadership parity between men and women is still decades off.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
也许同等重要的是，稳定或者下降的油价将会缓解通货膨胀压力使美国工人的工资更具有购买力。Renaissance Macro经济学家Neil Dutta 称“这对于国内需求来说是一个明确的积极的消息，人们将会有更多可以用来消费的钱”。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The post came after anonymous Internet users alleged that some questions and answers on the National Postgraduate Entrance Examination, which was held on Saturday and Sunday, were released in advance.
《癌症：众病之王》(Cancer: The Emperor of All Maladies)，PBS，3月30日播出。该剧由《斯科茨伯勒：美国的悲剧》(Scottsboro: An American Tragedy)与《美莱》(My Lai)的导演巴拉克·古德曼(Barak Goodman)执导，肯·伯恩斯(Ken Burns)担任执行制作人，这部六小时的剧集是根据普利策获奖书籍、悉达多·穆克吉(Siddhartha Mukherjee)医生的《众病之王：癌症传》(The Emperor of All Maladies: A Biography of Cancer)改编的。
A modular microarray imaging system for highly specific COVID-19 antibody testing
James Bond Themes 10. "Diamonds Are Forever" by Shirley Bassey
其他人将想方设法利用技术来帮助人们减少上网时间。谷歌(Google)前雇员特里斯坦哈里斯(Tristan Harris)发起的“时光莫虚度”(Time Well Spent)运动正在吸引人气，该运动鼓励设计者理解他们所控制的微妙的心理力量，以解决其所称的“数字注意力危机”。据Recode报道，曾经在Pinterest和Facebook工作的蒂姆肯德尔(Tim Kendall)，计划成立一家专注于对抗设备上瘾的初创公司。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Britain saw a 66 percent increase in its foreign-born population between 2004 and 2014. Voters who chose “leave” in the recent referendum overwhelmingly cited immigration as their main concern.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
According to the country's film regulator, China's box office sales have boosted a whopping 48.7 percent in the last year alone.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The government is keen to encourage lending to small and medium-sized borrowers, many of whom do not have credit histories. Analysts estimate the number of Chinese consumers who are financially active but without access to credit to be 500m.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
May the coming New Year bring you joy, love and peace.
A facile assay for rapid detection of COVID-19 antibodies
6. Cancer Mortality Rate
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
PwC has counted votes and provides winner envelopes for the Oscars and has done so for more than 80 years. This is the first time in Oscar history that the wrong envelope had been opened while an award was being announced.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
而在科隆游戏展上正式宣布的特色作品中，《寂静岭》（Silent Hills）的最新续集赫然在列。这是科乐美（Konami）最为畅销的恐怖题材游戏（还据此改编成了两部电影）。世界级游戏和电影专家，《合金装备5：幻痛》（Metal Gear Solid V: The Phantom Pain）的制作者小岛秀夫，以及《环太平洋》（Pacific Rim）的导演吉尔莫o德尔o托罗在这部游戏中强强联手。曾出演美剧《行尸走肉》（The Walking Dead）的影星诺曼o瑞杜斯将在游戏中担纲主角。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
1. What big brother is eating isn’t noodles, but loneliness.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The number of university graduates reached 7.65 million in 2016, hitting a new historic high, the Beijing News reported. Plus, the number of students graduating from secondary vocational schools hit 4.35 million, bringing the total figure to 12 million.
Anti-HIV drug repurposing against SARS-CoV-2
"He was not on the intelligence services' radar," added the prime minister.
“As we work to keep and attract more young professionals and job creators, we appreciate every young person who is engaged and invested in our state.”
Length-scale dependence of protein hydration-shell density
Several car names were among the top 50, from ‘ferrari’ to ‘mercedes.’
Coca-Cola said that the consumer slowdown in China had hit sales, and weaker demand was forcing it to drive down inventory.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Through an ETF buying programme that has been criticised by some as the “de facto nationalisation” of the Japanese stock market, the central bank indirectly holds a 10 per cent stake in some 22 large Japanese companies and about 3 per cent of the whole Japanese stock market.
Total Program Cost: $176,600
In the past 12 months, more than 20 provinces have introduced policies to encourage students to start their own companies by allowing them to quit studying but keep their student status for two to eight years. However, many industry insiders insist that students complete their studies and work a few years first.
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